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Bacterial Endotoxin for the Prevention of Metabolic Disorders and Bacterial Infections
Researcher: Dr. Burim Ametaj
On December 30, 2014, Dr. Burim Ametaj of the University of Alberta’s Department of Agricultural Food and Nutritional Science received a United State patent titled “Bacterial Endotoxin for the Prevention of Metabolic Disorders and Bacterial Infections” (serial no. 8,920,814).
Ruminant diets rich in starch lead to the development of metabolic disorders by changing the gastrointestinal microflora from fibre-digesting bacteria to starch-digesting bacteria. These starch-digesting bacteria, mostly Gram-negative bacteria, release large amounts endotoxins that are translocated into the host’s blood circulation triggering multiple perturbations associated with a variety of periparturient diseases such as ketosis, fatty liver, laminitis, displaced abomasum, milk fever, downer cow syndrome, udder edema, metritis, retained placenta, infertility and mastitis.
The University of Alberta researcher discovered that oral administration of Gram-negative bacterial endotoxin or lipopolysaccharide to dairy cows during the dry off period was effective in preventing the development of several of the those diseases.