Researchers at the University of Alberta in collaboration with Lakehead University have developed novel radiation-responsive block polymers for drug delivery. The nanoparticles are modified poly-L-glutamic acid (m-PGA) polymers which encapsulate one or multiple hydrophobic drugs, for example chemotherapeutic agents. Controlled release of drugs from the nanoparticles can be achieved by lysing the polymer by X-ray/gamma ray. This method of drug delivery and release improves drug efficacy and minimizes toxicity.
Drug delivery remains a challenge in management of cancer. Stimulus-responsive materials have attracted considerable attention as drug delivery systems for releasing therapeutic agents at sites of interest in response to various stimuli. However, the development of such stimuli-responsive materials for clinical use is slow because of various challenges including the safety of materials, stimulus sensitivity, response rate, and the complexity in manufacturing the final drug formulations. Therefore, there is a need to develop improved methods of drug delivery, particularly for the treatment of diseases such as cancer.
- The novel method and polymer composition provides a precision drug-delivery platform for multiple drugs.
- Improved drug efficacy and reduced toxicity.
We are seeking partners in the nanomedicine and cancer management space for collaborative development and licensing.
Technology Management Group
TEC Edmonton – University of Alberta