Dr. Dean Befus at the University of Alberta in collaboration with Dr. Thomas Ritz at the Southern Methodist University have identified calcium-binding protein spermatid specific 1 (CABS1) protein forms that can be used as predictive, diagnostic, and prognostic biomarkers for stress in humans.


Cortisol is one of the best known and most widely used biomarkers for stress because of its measurable and representative concentrations in saliva. However, commercially available cortisol based tests do not provide information about an individual`s responsiveness to stress situations. Thus, there is a market gap in point-of-care diagnostics for tests that can both predict and measure stress accurately and assist in devising stress management strategies in clinical settings.

CABS1 based diagnostic kit for measuring stress would have applications in several therapeutic indications such as acute stress syndrome, post-traumatic stress syndrome, respiratory distress syndrome (adult and neonatal), and acute respiratory distress syndrome. In addition, such kits can be used in diagnosis of clinical stress in students, people working in emergency situations (soldiers, first responders, doctors etc.) and people who have experienced traumatic events. The second commercial use, which differs from current stress biomarkers, is the potential to determine a person’s predisposition to respond to stress.

Publications (as of April 2016): PubMed 1


  • CABS1 can potentially be used to predict a person’s responsiveness to stress situations
  • Non-invasive saliva based test

Protection Status

US Provisional Patent

Product Number


Contact Information

Megha Bajaj
Technology Management Group
TEC Edmonton – University of Alberta
Phone: 780-492-7739