Novel F-18 Beta-Hydroxybutyric Acid Radiotracers for PET Imaging

Description

Researchers at the University of Alberta have synthesized novel beta-hydroxybutyric acid radiotracers for PET imaging using a 3 step radiosynthetic process. The compounds are designed to serve as radiofluorinated analogues of endogenous non-fluorinated metabolites. The biodistribution of the radiotracers in PET scans of normal mice show uptake in tissues that are difficult to visualize by […]

Automatic Measurement of Melanoma Breslow Depth

Description

Researchers at the University of Alberta have developed a method for rapid and accurate measurement of the melanoma Depth-of-Invasion (DoI), also known as Breslow Depth, from MART1 stained skin histopathological images. This method measures the melanoma DoI based on an accurate detection of melanoma regions and skin granular layer by using image color features and […]

Semiautomatic Segmentation of Nasal Cavity from Cone Beam CT Images

 

 
Description
We have developed a method for the rapid and highly accurate rendering of 3D models of the upper airways from 3D Cone Beam Computer Tomography (CBCT) scans.  Our method consists in one-time manual selection of seed points in a CBCT slice of the upper airway, with automatic repopulation of seed points in following slices, and […]

Distortionless UWB Antenna

Description
Ultra wideband (UWB) radio technology requires low power, offers high bandwidth efficiency, and is difficult to detect in covert applications compared to narrowband. It is used in radar imaging applications such as through-wall imaging, in internal medical diagnostics, environmental and weather monitoring, and security-related target tracking. Current UWB technologies rely on antennas that significantly distort […]

Fish on a Chip

Description
Fluorescence in situ hybridization (FISH) detects numerical and/or structural changes in chromosomes that occur in many types of genetic diseases, including cancer. The test involves permeabilizing cells, adding fluorescent tagged probes that attach to specific chromosomes and visualization of the probe-annealed chromosomes. Results are interpreted either by visual inspection and fluorescence microscopy, or a proprietary […]

Non-Repeating Interval Sequences for Coded Imaging and Multi-User Communications

Description
Coded excitation is widely used in ultrasound, radar, sonar and other imaging systems as well as in communication systems. Coded excitation involves the transmission of long-duration pulses with a time-bandwidth product (TBP) greater than 1. By coding the pulse on transmission, the received signals may be processed to compress (decode) the effective impulse response, and […]

Fluorinated Fructose Derivatives for PET Imaging

Description
Positron emission tomography (PET) is a non-invasive nuclear medicine imaging technique that produces a three-dimensional image of physiological processes and tissue microenvironments, which is used fordiagnosing and/or treating diseases including cancer, heart disease, and brain abnormalities. Traditionally,tumour imaging with PET relies on the use of the glucose analogue 2-deoxy-2-fluoro-D-glucose(FDG) as the imaging agent, which takes […]

Reduced Cost 3D Ultrasound Imaging

Description
Researchers at the University of Alberta have developed a cost-effective method for 3D ultrasound imaging that maintains image quality.

There are two traditional ways to accomplish 3D ultrasound imaging. The first method makes use of mechanically wobbled 1D arrays; however, this method has been shown to compromise imaging speed and quality. The second method uses 2D […]

Novel precursors for the PET radiotracer [18F]FAZA

Description
FAZA is a PET radiotracer that selectively accumulates in hypoxic cells. It was invented and developed at the Cross Cancer Institute of Alberta and is currently used in several medical centers to assess tumor hypoxia in cancer patients. FAZA shows improved tracer pharmacokinetics in comparison to other ‘first generation’ clinical hypoxia PET tracers, giving higher […]