Novel Diagnostic Tool for HIV – Associated Neurocognitive Disorder

Description

University of Alberta researchers, led by Dr. Christopher Power, have developed an innovative plasma-based diagnostic test for Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND). At present, clinically validated biomarkers are not available for the diagnosis of HAND. This novel test uses a minimal profile of three miRNAs to distinguish HAND from non-HAND patients.

Upon infection with […]

Plasma Protein Biomarkers for Fabry Disease

Description

Researchers at the University of Alberta have discovered novel plasma protein biomarkers in Fabry patients which can be used to develop diagnostic kits for patients with ambiguous mutations or non-specific symptoms. In addition, these biomarkers can also be used as prognostic markers for Fabry disease. Another application of these novel biomarkers can be in better […]

Novel Bio-markers for Diagnosis and Treatment of Stress

Description
Dr. Dean Befus at the University of Alberta in collaboration with Dr. Thomas Ritz at the Southern Methodist University have identified calcium-binding protein spermatid specific 1 (CABS1) protein forms that can be used as predictive, diagnostic, and prognostic biomarkers for stress in humans.
BACKGROUND
Cortisol is one of the best known and most widely used biomarkers for […]

Aptamers for the Diagnosis of Virulent Strep A Infections

Description
 

The Limitation of Point of Care Strep A Test Kits
Streptococcus A (“Strep A” or GAS) infections are associated with scarlet fever, necrotizing fasciitis, and “strep throat”. There are many different strains of microorganism within the Strep A group, but only a few are virulent and linked to serious human disease. These strains can be identified […]

Aptamers for the Detection of Hepatitis B

Description
Approx. 350 million people are chronically infected by hepatitis B virus (HBV), which is a major cause of liver cirrhosis and hepatocellular carcinomas. Diagnostic tests for this virus are requried for two major purposes: the diagnosis of infected individuals and the screening of blood samples to prevent transmission during blood transfusion. Several serologic markers are […]

Predictive marker for taxane responsiveness of cancer patients

Description
University of Alberta researchers have identified a predictive marker to screen patients that are being considered for taxane-based chemotherapy. Elevated levels of this protein marker correlate with increased breast cancer patient survival after adjuvant-taxane treatment. In vitro experiments using siRNA to knock-down protein expression demonstrate that the marker is a critical effector molecule in the […]