A Novel Method for CryoPreservation of Cells in Monolayers

Description

Researchers at the University of Alberta have developed a novel method to cryopreserve cells while adhered in a monolayer configuration. This method can preserve cells on a substrate and provide high post-thaw cell viability. Your company could then supply cryopreserved bioengineered cell monolayers directly in the desired configuration for immediate use.

 
Publication
Publication2018
Advantages

Allows cryopreservation of cells […]

Nanocrystalline Cellulose Hydrogel for Prevention of Bacterial Adhesion

Description

University of Alberta researchers have developed a hydrogel formulation by using a nanocrystalline cellulose (NCC) polymer that has potential to prevent biofilm formation via physical resistance mechanism.  Given that 80% of microbial infections in the body are caused by biofilms, preventing biofilm-formation via medical devices provides an effective strategy for prevention of bacterial infection.

The formulation […]

Novel Method for Purification of Short Insoluble Elastin-Like Polypeptides

Description

Researchers at the University of Alberta have developed a novel process to purify very hydrophobic elastin-like polypeptides (ELP). The method enables the expression and purification of ELPs that are poorly expressed and/or have very low transition temperatures. It uses denaturing metal affinity chromatography to recover ELPs from insoluble cell debris and pre-concentrate the target peptides […]

Biological Production of Fatty Alcohols from Carbohydrate Precursors

Description

University of Alberta researchers have genetically engineered a yeast platform for biosynthesis of long chain fatty alcohols from cellulosic hydrolysates. The engineering strategy included genetic modifications to endogenous yeast biosynthetic pathways as well as introduction of heterologous pathways. The primary fermentation products from this platform are saturated hexadecanol and octadecanol (C16 and C18, respectively), but […]

BioEngineered Adipocytes for the Light-Controlled Release of Insulin

Description

Dr. Peter Light at the University of Alberta has developed genetically engineered adipocytes that secrete significant amounts of bioactive insulin upon exposure to a particular wavelength of blue light. Insulin secretion is specific and very little insulin is secreted in the absence of light. This technology is currently being evaluated as an insulin replacement therapy […]

Photocleavable Affinity Tags for Ultra Pure Protein Purification

Description
Affinity tags are highly efficient tools for purifying proteins from crude extracts. However, most affinity purification elusion schemes require a change in buffer condition, such as addition of imidazole or a decrease in pH. This change in buffer conditions may cause some proteins that are non-specifically bound to the resin to elute as contaminants and […]

Enrichment of Oils with Polyunsaturated Fatty Acids

Description
Biologists have laboured for years to engineer various organisms for the genetic enrichment of oils with high levels of omega-3 long chain polyunsaturated fatty acids, because of the significant commercial interest for food and non-food applications. However, these attempts have not produced desired results. Often the omega-3 level is lower than expected and the produced […]

New Method of Managing Sclerotinia Sclertiorum

Description
Canola (Brassica sp) producers typically manage Sclerotinia sclertiorum, commonly known as white mould or stem rot, through crop rotations or fungicides; however, each method has a drawback. Crop rotations are often only effective if the rotation is relatively long (up to six years), and fungicides offer no protection once the crop shows signs of infection, […]

Development of Oils with High Punicic Acid Content

Description
Pomegranate (Punica granatum) seed oil has been attracting increased interest since it was shown that its main component punicic acid may provide a novel alternative therapeutic strategy for the treatment of inflammatory diseases. It can also be used as a dietary agent for prevention of prostate and breast cancer (Kim et. al., 2002; Shyed et. […]