Posted: October 25, 2019
FACULTY OF SCIENCE, DEPARTMENT OF CHEMISTRY
Team: Simon Ng, Seyed Mohammadreza Jafari
Patent 9,958,437: Method of quantifying peptide-derivative libraries using phage display
Phage display is an industry standard for development of peptide-based therapeutics and biological drugs. Classical phage display, however, works only with molecules comprised of 20 natural amino acids. Derda and his team pioneered the use of chemical reactions to introduce new chemical structures into phage-displayed libraries. Their patent protects a method for quantification of the yield of chemical reaction that modify peptides displayed on a phage. The method is comprised of:
i) reacting the phage-displayed peptide library with a reagent to derivatize the peptides;
ii) reacting the derivatized peptides with a capture agent;
iii) determining an amount of the phage with the capture agent, thereby quantifying the yield of the reaction.
The ‘capture agent’ technology can fuel development of many reactions thereby expanding the application of phage display to a chemical space beyond polypeptides made of a mere 20 amino acids.
The TEC Edmonton Innovation Awards celebrate the success of University of Alberta researchers. In 2019, awards were presented to ten University of Alberta spin-off companies and nine research teams that received a US patent and have an industry partner.