The respiratory tract has recently become an attractive route for administering a large range of molecules and drug substances.
Distributing drugs in this manner allows for local effectiveness in the treatment of various pulmonary diseases and minimizes the dosages and side effects. Furthermore, systemic absorption of drug compounds via the lungs has gained much attention due to the large surface area of the alveolar region and its small barrier between the airspace and bloodstream.
A new invention developed at the University of Alberta uses effervescent technology, normally used in tablets for oral administration, and applies this approach to the pulmonary and nasal routes. The invention involves a formulation containing a carbonate and an acid that effervesces in contact with moisture and can be used as a carrier particle device. This localized approach to delivering the desired ingredients results in quicker absorption and treatment of patients.