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A novel E. coli protein production system
Recombinant protein secreted into growth medium
Description
University of Alberta researchers have discovered that laboratory strains of E. coli secrete YebF, a native protein of unknown function, into the culture medium. Recombinant YebF fusion proteins are also secreted directly into the growth medium. As published in Nature Biotechnology 2006 Jan;24(1):100-4, secretion has been demonstrated with both hydrophilic and hydrophobic proteins; these fusion proteins exhibited excellent biological activity.
The ACES™ YebF Protein Export Kit is available exclusively through Athena Enzyme Systems.
Advantages
- Eliminates cellular lysis step in current E. coli protein production systems
- Reduces the need for protein solubilization and re-folding steps thus saving time and money
- Simplifies purification steps, reducing protein loss and contamination
- Potentially reduces endo-toxin contamination during therapeutic protein production
Potential Markets
- academic research
- industrial protein production
Protection Status
Patents Pending
Product Number
2004-009
Contact Information
Joanna Preston
780.492.7120
joanna.preston@tecedmonton.com
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DISCLAIMER:
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Although care has been taken in the preparation of this material to be as accurate as possible, the contents of this document are provided for information purposes only, and neither the University of Alberta nor the inventors offer any warranty, written or implied, as to the accuracy of the said contents.
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